Associate Chemist (RNA synthesis)


Arrowhead Pharmaceuticals, Inc. is a Nasdaq listed (ARWR) company that develops medicines to treat intractable diseases by silencing the causative genes. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference (RNAi) mechanism to induce rapid, deep and durable knockdown of target genes. RNAi is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead’s dynamic and innovative environment offers our employees the opportunity to advance revolutionary treatments for serious and intractable diseases. Our employees are creative and dedicated professionals who work collaboratively to our meet business and scientific challenges. Arrowhead’s R&D facility is located in the Research Park in Madison, WI.

The Position

Arrowhead Pharma is seeking an associate scientist to join the Chemistry Department. The successful candidate will be tasked with synthesis and analysis of RNA oligonucleotides. S/He will be expected to:

  • Within a team setting, learn aspects of RNA synthesis
    • Solid-phase oligonucleotide synthesis
    • Purify RNA oligonucleotides utilizing chromatography
    • Analyze synthetic targets employing HPLC, UV-Vis, and mass spectrometry
  • Maintain a well-documented laboratory notebook.
  • Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
  • Present finding in team meetings.
  • Adhere to safe laboratory practices.


The successful candidate should have a B.S. or M.S. chemistry or biochemistry degree with experience in a laboratory setting. The position is entry level with 0 to 3 years of industry experience. Good verbal and written communication skills as well proficiency with Word and Excel are required.


Experience working with both small molecule and large molecule synthetic targets either in an academic or industrial setting. Experience with a wide range of analytical techniques especially HPLC, MS and UV-Vis.

Competitive salary and excellent benefits package

All applicants must have authorization to work for Arrowhead in the U.S.

Please send resumes to  Include a cover letter that highlights your qualifications and matches our requirements.