Senior Medicinal Chemist


Arrowhead Pharmaceuticals, Inc. is a Nasdaq listed (ARWR) company that develops medicines to treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead’s dynamic and innovative environment offers our employees the opportunity to advance revolutionary treatments for serious and intractable diseases. Our employees are smart, creative, professionals who work collaboratively to meet our business and scientific challenges. Arrowhead’s R&D facility is located in the Research Park in Madison, WI.

The Position

Arrowhead is seeking a senior medicinal chemist to join our medicinal chemistry group within the Chemistry Department. The candidate will be a key member of drug discovery teams and may have opportunity to lead drug discovery programs. S/He will be expected to:

  • Multi-dimensional SAR analysis and hypothesis driven target molecule design.
  • Synthesis of small molecule and oligonucleotide compounds for drug discovery projects
  • Characterization and identification of compounds using modern analytical methods including HPLC, LCMS and NMR.
  • May lead medicinal chemistry effort in multidisciplinary drug discovery teams
  • Be creative and innovation in problem solving.


PhD degree with at least 3 years of drug discovery experience in pharmaceutical industry. Demonstrated achievement in syntheses and designs of bioactive compounds. Extensive knowledge in synthetic organic chemistry, both theoretical and practical. Solid understanding of pharmacology, PKPD and ADME concepts. Experience in lead optimization, SAR analysis and drug design. Excellent oral and written communication skills. Self-motivated learner.

All applicants must have authorization to work for Arrowhead in the U.S.

Please send resumes to  Include a cover letter that highlights your qualifications and matches our requirements.