Clinical Development

Associate Medical Director/Medical Director

Office Location: Pasadena, CA or San Diego, CA

Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

The Associate Medical Director/Medical Director will report to the head of cardiometabolic clinical development and will be instrumental in bringing important new therapies based on RNA interference to patients. This individual will work collaboratively with Arrowhead’s scientific and clinical teams to take drugs from late clinical research to NDA filings and will initially focus on siRNA programs targeting cardiac and metabolic (lipids and obesity) indications. Experience in these areas is encouraged but not required.   S/he will take hands on responsibility for designing and managing clinical studies to evaluate the efficacy, safety, dose selection and clinical pharmacology of product candidates.  Candidates with the requisite experience may be considered for a Medical Director title.


  • Support the conceptualization and design, development, execution and communication of clinical studies across a variety of therapeutic areas
  • Act as a medical lead in a cross functional team that includes medical, scientific, clinical, safety, program management and regulatory staff
  • Effectively communicate protocols and other relevant information with clinical site investigators and staff
  • Interpret clinical trial data and communicate results clearly and accurately
  • Provide ongoing clinical monitoring for clinical trials including but not limited to assessment of eligibility criteria, toxicity management, and drug safety surveillance
  • Contribute to documents, including IRB submissions, protocols, study reports, publications and regulatory submissions – including anticipated upcoming NDA/MAA submission
  • Provide high level and complex scientific and clinical guidance to Clinical Trials Management, Biometrics, Global Drug Safety, Regulatory and Project Management staff to meet project deliverables and timelines
  • Identify key opinion leaders and participate in clinical advisory board meetings
  • Make scientific presentations at advisory boards, key scientific meetings and external committee meetings
  • Identify and evaluate medical need and clinical path for new applications of RNA interference for the treatment of disease
  • Monitor and understand new developments in RNA interference in industry and academia
  • Support in-licensing and out-licensing activities and partner relationships


  • M.D., or Ph.D./M.D. combined with research experience
  • A strong desire to contribute to the development of meaningful therapeutics
  • Ability to effectively evaluate outside expert advice
  • Ability to clearly elucidate complex scientific and medical concepts via written and oral communication
  • Ability to work independently and effectively in a fast-paced, team-based, cross-functional environment
  • Strong interpersonal skills and the ability to communicate effectively with people in diverse and different settings
  • Excellent scientific communication skills (both verbal and technical) and interpersonal skills
  • Possesses sense of urgency without overlooking key details; identifies challenges and problems and takes the initiative to identify solutions
  • Results focused
  • Willingness to relocate if necessary to either Pasadena or San Diego, CA


  • Hands-on clinical research experience within a pharmaceutical or biotechnology company or in an academic setting
  • Fellowship training in relevant specialty (eg cardiology, endocrinology)
California pay range
$250,000$340,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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