Discovery Chemistry
Scientist, Discovery Med Chemistry
Office Location: San Diego, CA
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharma is seeking one skilled and motivated synthetic organic chemists.
Responsibilities
- Design and timely synthesize small molecules and peptides to support discovery projects
- Review research papers and intellectual property literature in support of SAR of oligonucleotide drug design and or delivery
- Track progress against project timelines, generate regular status updates and communicate progress and issues to team leaders
Requirements:
- Ph.D. in organic chemistry with 0 to 2 years of pharmaceutical industry experience, or M.S. degree with at least 5 years of experience in organic synthesis in the pharmaceutical industry
- Strong laboratory experience with analytical instruments, such as NMR, LC-MS, RP-HPLC, etc., is required
- Highly innovative and creative in problem solving
- Self-motivated with strong working ethics
- A good team player
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.