Discovery Chemistry

Sr. Scientist, Extrahepatic Targeting

Office Location: San Diego, CA

Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

The successful candidate will work in an interdisciplinary discovery team focusing on extrahepatic targeting. She/He will be an innovative leading scientist with the ability to work independently and collaboratively, design and carry out experiments and propose creative solutions to challenging problems.


  • Design and execute in vitro and in vivo studies to facilitate drug discovery and platform development in various disease areas
  • Develop, validate, and perform assays to characterize ligand-receptor interactions and to gain mechanistic understanding of drug delivery
  • Present research findings to project teams and governance bodies and prepare study reports
  • Maintain a high level of productivity in the lab and perform critical experiments
  • Guide junior scientists on the team


  • PhD in biology, bioengineering, biochemistry, or a related field with at least 5 years of relevant experience in biotech or pharmaceutical industry
  • Expertise in developing endpoint & kinetic assays, such as luminescence & fluorescence assays, activity assays, imaging-based assays
  • Strong background in characterization of ligand-receptor interactions using molecular, cellular, and biochemical approaches
  • Experienced in RNA isolation, real-time PCR, RNA-seq
  • Hands-on experience with cell culture and FACS cell sorting
  • Ability to adapt well to fast changing goals and research directions
  • Proven scientific accomplishments including publications, conference presentations or patents


  • Knowledge and experience with protein sciences
  • Familiarity with various therapeutic areas


California pay range
$140,000$170,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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