Associate Scientist, Chemistry


Arrowhead Pharmaceuticals, Inc. is a Nasdaq listed (ARWR) company that develops medicines to treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead’s dynamic and innovative environment offers our employees the opportunity to advance revolutionary treatments for serious and intractable diseases. Our employees are smart, creative, professionals who work collaboratively to meet our business and scientific challenges. Arrowhead’s R&D facility is located in the University Research Park in Madison, WI.

The Position

Arrowhead Pharmaceuticals is seeking an Associate Scientist to join the Chemistry Department. The successful candidate will primarily focus on bioconjugation, analytical chemistry, formulation, and some small molecule organic synthesis. S/He will be joining a team of highly motivated and experienced scientists, and will contribute to the success of Arrowhead programs.  S/He will be expected to:

  • Perform bioconjugation, purification, and characterization of oligonucleotide conjugates.
  • Identify critical issues/steps in a conjugation and solve the problems in a timely fashion.
  • Maintain a well-documented laboratory notebook.
  • Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
  • Present findings in team meetings.
  • Adhere to safe laboratory practices.
  • Multi-task across several projects and manage time effectively to achieve results.


The successful candidate should have a B.S. or M.S. chemistry or biochemistry degree with excellent understanding of organic and analytical chemistry.  Experience working in an organic synthesis laboratory or analytical laboratory is required.  Experience with a wide range of analytical techniques, especially HPLC and/or HPLC-MS is required.


Experience working with both small molecule and large molecule synthetic targets (especially oligonucleotides) either in an academic or industrial setting is preferred.

All applicants must have authorization to work for Arrowhead in the U.S.

Please send resumes to  Include a cover letter that highlights your qualifications and matches our requirements.