Arrowhead to Present at Upcoming February Conferences
PASADENA, Calif.–(BUSINESS WIRE)–
Arrowhead Research Corporation (NASDAQ: ARWR), a biopharmaceutical
company developing targeted RNAi therapeutics, today announced that the
company will make presentations at the following upcoming events.
25th Conference of the Asian Pacific
Association for the Study of the Liver – Tokyo, February 20-24, 2016
February 22, 1:30 p.m. JST – Man-Fung Yuen, M.D., Ph.D., chair of
gastroenterology and hepatology, The University of Hong Kong, and deputy
chief of service, Queen Mary Hospital department of medicine, Hong Kong,
and coauthors, will deliver an oral presentation titled, “Effective
Inhibition of cccDNA Derived mRNA/Viral Antigens and Tolerability with
ARC-520”
2016 RBC Capital Markets’ Global Healthcare Conference – New
York, February 23-24, 2016
February 23, 9:30 a.m. EST – Chris Anzalone, Ph.D., Arrowhead
president and chief executive officer, and David Lewis, Ph.D., Arrowhead
chief scientific officer, will participate in a fireside chat with
Michael Yee, managing director – biotechnology equity research, RBC
Capital Markets
Webcast links and copies of presentation materials can be accessed by
visiting the Events section of the company’s website at http://ir.arrowheadresearch.com/events.cfm.
About ARC-AAT
Arrowhead’s ARC-AAT is being investigated for the treatment of liver
disease associated with alpha-1 antitrypsin deficiency (AATD), a rare
genetic disease that severely damages the liver and lungs of affected
individuals. The mean estimated prevalence of AATD in the U.S. is 1 per
3000-5000, or approximately 100,000 patients. AATD is also an important
cause of pediatric liver disease with an estimated prevalence in
children of approximately 20,000 patients, and 50-80% likely to manifest
liver disease during childhood. It is a rare disease that appears to be
frequently misdiagnosed or undiagnosed. ARC-AAT employs a novel unlocked
nucleobase analog (UNA) containing RNAi trigger molecule designed for
systemic delivery using the Dynamic Polyconjugate™ delivery
system. ARC-AAT is highly effective at knocking down the Alpha-1
antitrypsin (AAT) gene transcript and reducing the hepatic production of
the mutant AAT (Z-AAT) protein in animal models. Reduction of liver
production of the inflammatory Z-AAT protein, which is believed to be
the cause of progressive liver disease in AATD patients, is important as
it is expected to halt the progression of liver disease and potentially
allow fibrotic tissue repair. ARC-AAT was granted orphan drug
designation in both the United States and in Europe, the latter being
held on Arrowhead’s behalf by a local EU representative Pharma Gateway
AB. Arrowhead is conducting a Phase 1 clinical study of ARC-AAT, with
part A in healthy volunteers and part B in AATD patients.
About ARC-520
Arrowhead’s RNAi-based candidate ARC-520 is being investigated in the
treatment of chronic HBV infection. The small interfering RNAs (siRNAs)
in ARC-520 intervene at the mRNA level, upstream of the reverse
transcription process where current standard of care nucleotide and
nucleoside analogues act. Arrowhead is investigating ARC-520
specifically to determine if it can be used to achieve a functional
cure, which is an immune clearant state characterized by hepatitis B
s-antigen negative serum with or without seroconversion. Approximately
350-400 million people worldwide are chronically infected with the
hepatitis B virus, which can lead to cirrhosis of the liver and is
responsible for 80% of primary liver cancers globally. Arrowhead is
currently conducting Phase 2b multiple dose and combination studies in
chronic HBV patients. In clinical studies to date, the most common
reported adverse events in all subjects completing treatment were upper
respiratory infection and headache.
About Arrowhead Research Corporation
Arrowhead Research Corporation is a biopharmaceutical company developing
targeted RNAi therapeutics. The company is leveraging its proprietary
Dynamic Polyconjugate™ delivery platform to develop targeted
drugs based on the RNA interference mechanism that efficiently silences
disease-causing genes. Arrowhead’s pipeline includes ARC-520 and ARC-521
for chronic hepatitis B virus, ARC-AAT for liver disease associated with
alpha-1 antitrypsin deficiency, ARC-F12 for hereditary angioedema and
thromboembolic diseases, and ARC-HIF2 for renal cell carcinoma.
For more information please visit http://www.arrowheadresearch.com,
or follow us on Twitter @ArrowRes.
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Safe Harbor Statement under the Private Securities Litigation Reform
Act:
This news release contains forward-looking statements within the
meaning of the “safe harbor” provisions of the Private Securities
Litigation Reform Act of 1995. These statements are based upon our
current expectations and speak only as of the date hereof. Our actual
results may differ materially and adversely from those expressed in any
forward-looking statements as a result of various factors and
uncertainties, including our ability to finance our operations, the
future success of our scientific studies, our ability to successfully
develop drug candidates, the timing for starting and completing clinical
trials, rapid technological change in our markets, and the enforcement
of our intellectual property rights. Arrowhead Research Corporation’s
most recent Annual Report on Form 10-K and subsequent Quarterly Reports
on Form 10-Q discuss some of the important risk factors that may affect
our business, results of operations and financial condition. We assume
no obligation to update or revise forward-looking statements to reflect
new events or circumstances.
DYNAMIC POLYCONJUGATES is a trademark of Arrowhead Research
Corporation.
Source: Arrowhead Research Corporation
View source version on businesswire.com: http://www.businesswire.com/news/home/20160216006730/en/
Arrowhead Research Corporation
Vince Anzalone, CFA
626-304-3400
ir@arrowres.com
or
Investor
Relations:
The Trout Group
Chad Rubin
646-378-2947
ir@arrowres.com
or
Media:
Russo
Partners
Matt Middleman, M.D.
212-845-4272
matt.middleman@russopartnersllc.com
Source: Arrowhead Research Corporation
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