Clinical Pharmacology and DMPK
Associate Scientist, DMPK
Office Location: Madison, WI
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking an Associate Scientist I to join the DMPK team. The Associate Scientist I will be primarily focused on performing routine bioanalytical sample analysis. S/He will be joining a team of highly motivated and experienced chemists and biologists and contribute to the success of Arrowhead.
Responsibilities
- Perform routine quantitative bioanalysis in a variety of biological matrices (fluids and tissues) in support of DMPK pharmacokinetic and biodistribution pre-clinical studies under minimal supervision.
- Generate reliable and reproducible data in a timely manner. Analyze, organize, and manage data independently. Present findings to the broader DMPK team.
- Conduct peer review of data.
- Setup and maintain lab instrumentation such as HPLC-FL and LC-MS/MS systems.
- Evaluate assay and instrument performance, ability to troubleshoot minor issues.
- Maintain a well-documented laboratory notebook.
- Follow safe laboratory practices.
Requirements:
- Bachelor’s degree in chemistry or related scientific field with a minimum of one year of experience in pharmaceutical/CRO industry.
- Familiarity with commonly used lab equipment such as analytical balances, bench top centrifuges, and pipettes.
- Experience with a wide range of analytical techniques, especially HPLC and/or HPLC-MS.
- Self-motivated team player with the ability to thrive in a fast paced, dynamic, multi-disciplinary, matrixed environment.
- Strong communication, teamwork, and time management skills with demonstrated effective interpersonal and written/verbal communication.
Preferred:
- Preferred experience with bioanalytical sample analysis (regulated or non-regulated).
- Preferred familiarity with GxP regulatory guidance.
- Preferred familiarity with Good Documentation Practices.
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.