Biology
Associate Scientist II, Molecular Biology
Office Location: Madison, WI
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
We are searching for an Associate Scientist II to join the Translational Biomarkers Team in Madison, WI. In this critical role, you will play a key part in supporting the development and execution of assays for clinical trial samples. This position provides an opportunity to demonstrate your attention to detail, strong record-keeping capabilities, and ability to collaborate across functions while leveraging your technical expertise.
Responsibilities
- Propose innovative methods and strategies to optimize plate-based functional assays, significantly contributing to our research efforts.
- Perform plate-based functional assays that lead to groundbreaking discoveries.
- Engage in gene expression and functional analysis using a variety of methodologies.
- Assist the team in developing and validating new targets that have the potential to result in transformative therapies.
- Occasionally present your research findings to project teams and governance bodies, while preparing internal technical reports that reflect your contributions.
- Stay informed by reviewing relevant scientific literature and suggesting applications to projects to address challenges and provide solutions.
- Maintain high productivity and quality in the laboratory, ensuring excellence in every experiment.
- Conduct critical experiments
- Maintain meticulous records and conduct activities in accordance with GCLP best practices, ensuring our work adheres to the highest standards.
Requirements
- Bachelor of Science in Biology or a related field
- 3+ years of experience in cell biology, molecular biology, immunology, pharmacology, or a related field, OR a Master’s Degree in Biology or a related field with 1+ years of experience.
- Proficiency in standard cellular and molecular biology techniques such as cell culture, ELISA, plate-based assays, and immunofluorescence.
- Demonstrated ability to innovate, think creatively, and exhibit resilience in problem-solving.
- Excellent oral and written communication skills that enable you to effectively convey your enthusiasm for science.
- A self-motivated team player who excels in a fast-paced, multi-disciplinary, matrixed environment.
Preferred
- Experience in pulmonary, cardiovascular, CNS, or metabolic disease
- A foundational understanding of commonly used RNA and protein assays
- Protein purification experience
- Assay development & validation
- Experience authoring SOPs
- RNA/DNA isolation and qPCR
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.