Discovery Chemistry
Associate Scientist, Bioanalysis
Office Location: Madison, WI
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
Arrowhead Pharmaceuticals is seeking a Scientist to join the Chemistry Department. The successful candidate will primarily focus on analysis of biological samples using bioanalytical assays including qPCR and ELISA to support drug discovery programs.
Responsibilities
- Perform qPCR and ELISA based quantitative bioanalysis in a variety of biological matrices (including biofluids and tissues) to support pharmacokinetics and tissue clearance studies
- Follow sample analysis SOPs
- Process, review, and interpret data independently
- Track progress against project timelines, generate regular status updates, and communicate progress and issues to management
- Submit ADME study requests
- Understand program or study design, generate figures to present data accordingly, and share bioanalysis results to cross-function groups
- Setup and maintain lab instruments
- Maintain a well-documented laboratory notebook. Document experimental procedure and results accurately and meticulously
- Demonstrate well-established sample analysis, troubleshooting and problem-solving skills
- Execute all assays in a timely manner to meet deadlines
- Be able to address questions or concerns related to bioanalysis running conditions and data analysis criteria
- Adhere to safe laboratory practices
Requirements:
- BS degree in biology, chemistry, or related field
- 5+ years of experience in the pharmaceutical/CRO industry or MS degree with 3+ years of experience
- Hands-on experience of quantitative bioanalysis techniques like qPCR or ELISA
- Hands-on experience of sample handling from biological matrices
- Demonstrated innovation, creativity and resilience in problem solving
- Excellent oral and written communication skills
- Self-motivated team player with the ability to thrive in a fast paced, dynamic, multi-disciplinary, matrixed environment
Preferred:
- Stem-loop qPCR method development or validation experience
- ELISA or immunoprecipitation method development or validation experience
- LCMS sample preparation or data analysis experience
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.