CMC
Director, Commercial Supply Chain
Office Location: Pasadena, CA or Verona, WI
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI and San Diego, CA. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The Director, Commercial Supply Chain plays a critical role in managing the global supply chain operations for Arrowhead’s SiRNA pharmaceutical products. This individual will ensure a clear supply chain strategy to support global markets, coordinate global strategies, focus on supply chain launch readiness for all new commercial products, and require strong cross-functional collaboration with product development teams. The candidate will drive process improvements, enhance supply planning capabilities, and ensure compliance with global regulatory requirements while managing complex global operations within a GxP environment.
Responsibilities
- Accountable for providing an uninterrupted supply of quality products to our patients both domestically and globally.
- Accountable for planning and execution for new product launches, line extensions or site manufacturing changes in collaboration with appropriate department stakeholders.
- Responsible for management, development, and support of commercial supply chain team comprised of commercial supply management, operations network and strategy, commercial label and artwork, packaging engineering, and device engineering.
- Accountable for department SOPs to ensure consistency and compliance in commercial supply chain activities.
- Monitor execution of supply plans and collaborate with Global Commercial Supply Management to resolve any deviations from supply plans and escalations to contract manufacturers.
- Identify, assess, and mitigate supply chain risks, including potential supply disruptions and regulatory compliance challenges.
- Resolve escalated commercial supply and delivery related issues as vital through collaboration with other departments.
- Develop and implement company-wide policies and strategies for commercial materials management to improve cost control, asset management, and compliance.
- Responsible for commercial supply chain coordination of US and international markets, from raw materials to finished goods
- Responsible for execution of global market supply chain strategies
- Accountable for strategic evaluations/decisions linked to new sites, site extensions, external network CMO’s and business continuity needs while partnering with Strategic Sourcing and Procurement in vendor selection and negotiation.
- Drive global strategic initiatives regarding manufacturing and distribution networks
- Knowledgeable and responsible for supply chain inputs and support for regulatory filings
- Develop supply chain launch capabilities to support new product introductions
- Act as Supply Chain representative on launch readiness teams
- Accountable for S&OP process to align supply with actual demand. Develop and communicate performance indicators and coordinate cross-functional work teams to increase efficiency and effectiveness of the complete supply chain and minimize risk of obsolescence or supply interruptions.
- Develop and integrate KPIs to drive continuous improvement
- Identify and implement continuous improvement initiatives to enhance supply chain agility and responsiveness.
- Other duties as assigned
Requirements
- BS in Business Administration, Supply Chain/Logistics, Engineering, or other field related to the essential duties of this role.
- 10+ years of increasing responsibility in Supply Chain and Manufacturing, focused on the pharmaceutical industry (7+ years in fast paced cGMP environments; 5+ years in a supply chain leadership role within the pharmaceutical industry, including direct people management.)
- Previous experience with product launches.
- Exhibits excellent interpersonal communication, project management, collaboration, and analytical skills and can speak to all levels of internal employees as well as outside third-party customer and strategic alliance partners.
- Strong MS Excel, PowerPoint, and Word skills.
- Experience using Smartsheet or other work management software.
- Proficient generating and presenting operational and financial metrics/KPI’s.
- Thorough understanding of ICH/GMP requirements for raw materials used in the manufacture of drug substances.
- Quick learner with the ability to handle multiple tasks simultaneously, maintain focus, and adapt to a variety of challenges.
- Exhibits creativity in adapting to changing situations, development of contingency plans and comfortable with making decisions.
Preferred:
- MBA or advanced life science degree
- Specialized or technical knowledge licenses and/or certifications, APICS Certification is preferred
- Prior experience with developing and setting up a supply chain infrastructure in a start-up environment
- Strong knowledge of international importing/exporting shipping, CBP compliance, and EU VAT compliance with governmental reporting abilities.
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.