Finance

Manager, Order-to-Cash (O2C)

Office Location: Verona, WI

Arrowhead Pharmaceuticals, Inc. (Nasdaq:  ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI.  Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

We are seeking an experienced Manager, Order-to-Cash (O2C) to design, implement, and manage end-to-end finance-related processes for our first commercial product launch. This is a foundational role within the finance function, responsible for establishing and managing the O2C lifecycle, including sales order processing, invoicing, accounts receivable, cash application, and customer finance management.

The ideal candidate brings a strong track record of setting up scalable, compliant O2C processes in a life science company, and thrives in a fast-paced environment. This role requires deep cross-functional collaboration, particularly with Commercial, Supply Chain, IT, Finance and Accounting, Legal and Distribution Partners.

Responsibilities

  • Order-to-cash Process Ownership
    • Work closely with Commercial, Supply Chain, IT, Accounting, distributors, wholesalers and other customers to design and implement all aspects of the O2C cycle to support product sales in the US and Globally in an ERP environment with future electronic data interchange (EDI) capability.
    • Develop scalable processes for:
      • Sales order entry and validation
      • Customer invoicing
      • Customer credit management and collections
      • Returns and chargeback processing
      • Cash application and dispute management.
  • Customer Engagement
    • Act as the primary finance contact for distributors, specialty pharmacies, wholesalers, and other customers.
    • Resolve payment discrepancies and manage credit/debit memos.
    • Support returns, pricing disputes, and chargeback processes, ensuring alignment with commercial agreements.
  • Systems and Compliance
    • Support the implementation of O2C processes in Dynamics 365, consider interfaces and ways to streamline processes and improve controls.
    • Work with Director Internal Audit and auditors to establish new SOX controls and ensure ongoing compliance in each market.
    • Develop and maintain standard operating procedures (SOPs) and control documentation.
    • Familiar with Good Manufacturing Practices (GMP) environments.
  • Cross-functional Collaboration
    • Partner with Commercial and Accounting to align revenue recognition, product pricing, and GTN (Gross-to-Net) considerations.
    • Coordinate with IT to enable data flows between order systems, ERP, and reporting tools.
    • Liaise with Commercial, Distribution, Legal, Accounting to ensure return processes and customer terms are compliant.
  • Reporting and Continuous Improvement
    • Monitor and report on key O2C metrics: DSO, AR aging, dispute resolution cycle time, etc.
    • Continuously assess and improve processes, systems, and service delivery.
    • Support monthly close, audit, and revenue cycle reporting requirements.

Requirements

  • Bachelor’s degree in Finance, Accounting, Business, or related field
  • 5+ years of relevant experience in biotech/pharma, with exposure to international commercial operations.
  • Proven success implementing O2C processes from the ground up, especially in a launch environment.
  • Experience with ERP systems (e.g., D365, SAP, NetSuite, Oracle), EDI, and order management platforms.
  • Experienced with SOX compliance, 3PL, and gross-to-net concepts.
  • Strong understanding of revenue cycle, trade operations, and customer financial services.
  • Excellent analytical, communication, and interpersonal skills.
  • Comfortable navigating ambiguity and scaling operations in a growing organization

Preferred

  • Launch-stage biotech or pharma company experience.
  • Understanding of specialty distribution models and US/CA/EU market dynamics.
Wisconsin pay range
$112,000$130,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.   

All applicants must have authorization to work in the US for a company.   

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