Biology
Manager, Translational Biomarkers Operations & Sample Management
Office Location: Madison, WI
Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a clinical stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing.
Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.
Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
The Position
The Translational Biomarkers Operations & Sample Management Manager is a critical operational leader within the Translational Biomarkers team. This hybrid role is responsible for overseeing laboratory operations, clinical sample management, biorepository governance, and digital workflow implementation to support translational and clinical research programs.
This position ensures operational efficiency, regulatory compliance, audit readiness, and seamless coordination between internal stakeholders and external collaborators. The role requires strong organizational leadership, technical understanding of clinical sample handling, and the ability to implement scalable systems that support evolving program needs.
Responsibilities
- Co-Lead/Lead day-to-day laboratory operations, including purchasing, expense tracking, invoice approvals, and budget support
- Coordinate instrument and pipette maintenance and maintain audit-ready documentation
- Develop, review, and maintain SOPs and standardized workflows
- Oversee scheduling, tracking, and reconciliation of clinical sample shipments
- Manage a compliant biorepository of clinical, preclinical, and procured samples
- Implement and maintain sample tracking and laboratory workflows in ELN/LIMS
- Partner with cross-functional teams (QA, IS&I, USDM, Clinical Operations) to ensure system adoption and compliance
- Ensure regulatory compliance and patient privacy protections in all sample handling activities
- Support planning and execution of clinical sample processing, including reagent procurement and workflow validation
- Maintain centralized documentation systems, vendor logs, and master schedules
- Facilitate operational communication and coordination within the Translational Biomarkers team
Requirements
- Bachelor’s degree in Life Sciences, Biotechnology, or a related field with 5+ years of experience or Master’s degree with 2+ years of experience
- Experience in clinical sample management and laboratory operations
- Understanding of regulatory requirements for clinical sample handling
- Proficiency with laboratory information management systems (LIMS) and other relevant software (Benchling preferred)
- Excellent organizational skills and attention to detail
- Strong communication and interpersonal skills
- Ability to work collaboratively in a team environment
- Problem-solving skills and ability to manage multiple tasks simultaneously
- Strong team orientation and passion for continuous self-development
- Arrowhead provides competitive salaries and an excellent benefit package
- All applicants must have authorization to work in the US for a company
Preferred
- Biotech or biopharma industry experience
- Experience in startup or high-growth environments
- Experience implementing laboratory workflow systems
- Experience supporting translational or assay development teams
Arrowhead provides competitive salaries and an excellent benefit package.
All applicants must have authorization to work in the US for a company.