Associate Scientist, Chemistry


Arrowhead Pharmaceuticals, Inc. is a Nasdaq listed (ARWR) company that develops medicines to treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead’s dynamic and innovative environment offers our employees the opportunity to advance revolutionary treatments for serious and intractable diseases. Our employees are smart, creative, professionals who work collaboratively to meet our business and scientific challenges. Arrowhead’s R&D facility is located in the University Research Park in Madison, WI.

The Position

Arrowhead Pharma is seeking an associate scientist to join the Chemistry Department. The successful candidate will be mainly tasked with organic synthesis and medicinal chemistry. S/He will be joining a team of highly motivated and experienced medicinal chemists, and contribute to the success of Arrowhead programs.  S/He will be expected to:

  • Perform synthesis, purification, and characterization of organic molecules.
  • Identify critical issues/steps in a synthesis and solve the problems in a timely fashion.
  • Maintain a well-documented laboratory notebook.
  • Track progress against project timelines, generate regular status updates, and communicate progress and issues to management.
  • Present finding in team meetings.
  • Adhere to safe laboratory practices.
  • Energetic, self-motivated and hard working.


The successful candidate should have a B.S. or M.S. chemistry or biochemistry degree with excellent understanding of organic chemistry.  Experience working in an organic synthesis laboratory and good lab techniques are required.  Experience with a wide range of analytical techniques especially TLC, HPLC, MS and NMR is required.


Experience working with both small molecule and large molecule synthetic targets either in an academic or industrial setting, and experience in working in medicinal chemistry and carrying out SAR studies are preferred.

All applicants must have authorization to work for Arrowhead in the U.S.

Please send resumes to  Include a cover letter that highlights your qualifications and matches our requirements.